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14I1O08 - Biochemistry (including basic molecular biology)

Course specification
Course titleBiochemistry (including basic molecular biology)
Acronym14I1O08
AcronymVeterinary Medicine
Module
Type of studyIntegrated academic studies
Lecturer (for classes)
  1. prof. dr Ivan Jovanović
  2. doc. dr Olivera Valčić
  3. prof. dr Svetlana Milanović
Lecturer/Associate (for practice)
  1. prof. dr Ivan Jovanović
  2. prof. dr Svetlana Milanović
  3. doc. dr Olivera Valčić
Lecturer/Associate (for OTC)
    ESPB7.0Status
    ConditionMedical Chemistry
    The goalStudents will understand the key principles of: the structure and functions of biological molecules , metabolic processes, storing, inheritance, and expression of genetic information. Biochemistry course will also prepare students to fully understand programs of subsequent academic years.
    The outcomeAfter the completion of the course, students will know: principles of structure and functions of proteins, lipids, carbohydrates and nucleic acids; key metabolic pathways, mechanisms of their regulation, metabolic energy yield and needs in cells and tissues; specific metabolic adaptations of ruminants; mechanisms of storing, inheritance and expression of genetic information; theoretical and practical basis of biochemical laboratory methods.
    Contents
    Contents of lecturesAmino acids; peptide bond; week interactions; primary protein structure. Structure of proteins. Collagen, myoglobin & hemoglobin, oxygen binding and transport; immunoglobulin G. Enzymes: bio-energetics, catalytic action, isozymes & multi-enzyme complexes; kinetics & regulation; coenzymes; nomenclature. Biological membranes: structure; transport across membranes, hormone signal transduction. DNA & RNA structure. Replication & reparation. RNA transcription & editing. Protein synthesis; genetic code. General metabolism & ATP synthesis. Carbohidrates: digestion, absorption & transpor; inter-conversion of hexoses; pentose phosphate pathway. Glycogen metabolism & regulation. Glucose metabolism: glycolyisis & regulation, in erythrocytes; gluconeogenesis; pyruvate & lactate axis; Cori cycle. Citric acid cycle & regulation; metabolic modifications of the CAC. Lipids: Digestion, absorption & transport of lipids; lipoproteins, fat storages & mobilization. Fatty acids: oxidation, free radicals & antioxidative protection, synthesis, ketone bodies. Triglyceride & phosphoglycerides: synthesis, biological roles. E eicosanoids. Cholesterol metabolism. Proteins: digestion, absorption & transport of amino acids; amino acids metabolism strategy. Metabolism of amino-nitrogen: transamination, desamination, urea cycle; decarboxilation & biologically active amines. Metabolism of the amino acid carbon backbone. Metabolism of heme; metabolism of nucleotides. Special features of ruminant metabolism.
    Contents of exercisesSolutions, pH, buffers; proteins: chemical characteristics, concentration determination; milk; molecular separation methods: electrophoresis, chromatography, centifugation; enzymes: AP, LDH, AST, ALT; carbohydrates; lipids and cholesterol.
    Literature
    1. Mihailović MB, Jovanović IB: Biochemistry, 5th ed, Naučna, Belgrade, 2008.
    2. Jovanović IB, Valčić O. Milanović S.: Biochemistry Practicals, 3rd ed., CID, Beograd, 2015.
    3. Berg JM, Tymoczko JL, Stryer L: Biochemistry, 5th ed, WH Freeman & Co, New York, 2002. (Original title)
    4. Voyet D, Voyet J: Biochemistry, 3rd ed, Wiley, New York, 2004. (Original title)
    Number of hours per week during the semester/trimester/year
    LecturesExercisesOTCStudy and ResearchOther classes
    43
    Methods of teachingTheoretical lectures with multimedia presentation, laboratory practicals, regular and appointed group consultations.
    Knowledge score (maximum points 100)
    Pre obligationsPointsFinal examPoints
    Activites during lectures4Test paper0
    Practical lessons6Oral examination70
    Projects0
    Colloquia20
    Seminars0